Unleashing the Power of Natural Killer Cells: A New Horizon in Cancer Therapy
Discover the transformative power of Natural Killer (NK) cells in cancer therapy. This blog post delves into the innovative use of CAR NK-Cell Therapy, which harnesses the body’s own immune system to target and destroy cancer cells more efficiently. Learn about the science behind NK cells, their unique capabilities in recognizing and eliminating cancer cells, and the latest advancements in immunotherapy that are setting new standards in cancer treatment. Join us in exploring how these breakthroughs are paving the way toward more effective and less invasive cancer therapies.
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors Infusion of CAR-NK Cells Summary This study investigates HLA-mismatched anti-CD19 CAR-NK cells derived from cord blood to patients with relapsed CD19-positive cancers (non-Hodgkin’s lymphoma or chronic lymphocytic leukemia .The results suggest that the majority of the patients had a response to treatment with CAR-NK cells […]
Next-generation cell therapies: the emerging role of CAR-NK cells
Next-generation cell therapies: the emerging role of CAR-NK cells Receptors in Detail Summary T cells with chimeric antigen receptors (CARs) have transformed cell therapy and shifted the treatment paradigm for many patients with recurrent or refractory B-cell malignancies. Despite this advancement, CAR-T cell treatment has limits in both autologous and allogeneic contexts, including practical, logistical, […]
CAR NK therapy attacks cancer quickly
CAR NK therapy offers experimental treatment option Overall Survival Summary Natural killer cells – or NK cells – are part of our immune system. They patrol our bodies for abnormal cells like cancer and destroy them. But cancer cells can make themselves invisible, making it much more difficult for NK cells to find them and […]
CAR-NK cells: A promising cellular immunotherapy for cancer
CAR-NK cells: A promising cellular immunotherapy for cancer Overall Survival Summary Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the remarkable success of chimeric antigen receptor (CAR)- engineered T (CAR-T) cells for treating haematological malignancies, there is a […]
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy Summary Natural killer (NK) cells are specialized immune cells that can be genetically manipulated to produce capable effector cells for adoptive cellular therapy of cancer patients due to their rapid detection and lysis of malignant cells. However, biological and technical barriers to […]
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany Chimeric Antigen Receptors Summary Chimeric antigen receptor-T cell therapies are poised to become powerful immunotherapeutic tools for combating hematological diseases, which have a pressing need for treatment. Patients characteristics Recently, CAR-NK cell therapy has also come be the focus of new treatment options […]
Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines
Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines Patient derived Melanoma Cell Lines Summary We describe the development, optimization, and validation of 384-well growth inhibition assays for six patient-derived melanoma cell lines (PDMCLs), three wild type (WT) for BRAF and three with V600E-BRAF mutations. We conducted a pilot drug combination (DC) high-throughput […]
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany Summary CAR-NK cell therapies have risen to prominence as a unique therapeutic alternative for overcoming challenges associated with CAR-T cell therapies, such as therapy-induced side effects. More than 500 CAR-T and 17 CAR-NK cell trials are currently underway around the world, including […]
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy Summary Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically modified to obtain capable effector cells for adoptive cellular treatment of cancer patients. Recent technological advancements, including […]
