Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors Infusion of CAR-NK Cells Summary This study investigates HLA-mismatched anti-CD19 CAR-NK cells derived from cord blood to patients with relapsed CD19-positive cancers (non-Hodgkin’s lymphoma or chronic lymphocytic leukemia .The results suggest that the majority of the patients had a response to treatment with CAR-NK cells […]
Next-generation cell therapies: the emerging role of CAR-NK cells
Next-generation cell therapies: the emerging role of CAR-NK cells Receptors in Detail Summary T cells with chimeric antigen receptors (CARs) have transformed cell therapy and shifted the treatment paradigm for many patients with recurrent or refractory B-cell malignancies. Despite this advancement, CAR-T cell treatment has limits in both autologous and allogeneic contexts, including practical, logistical, […]
CAR NK therapy attacks cancer quickly
CAR NK therapy offers experimental treatment option Overall Survival Summary Natural killer cells – or NK cells – are part of our immune system. They patrol our bodies for abnormal cells like cancer and destroy them. But cancer cells can make themselves invisible, making it much more difficult for NK cells to find them and […]
CAR-NK cells: A promising cellular immunotherapy for cancer
CAR-NK cells: A promising cellular immunotherapy for cancer Overall Survival Summary Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the remarkable success of chimeric antigen receptor (CAR)- engineered T (CAR-T) cells for treating haematological malignancies, there is a […]
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy Summary Natural killer (NK) cells are specialized immune cells that can be genetically manipulated to produce capable effector cells for adoptive cellular therapy of cancer patients due to their rapid detection and lysis of malignant cells. However, biological and technical barriers to […]
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany Chimeric Antigen Receptors Summary Chimeric antigen receptor-T cell therapies are poised to become powerful immunotherapeutic tools for combating hematological diseases, which have a pressing need for treatment. Patients characteristics Recently, CAR-NK cell therapy has also come be the focus of new treatment […]
Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines
Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines Patient derived Melanoma Cell Lines Summary We describe the development, optimization, and validation of 384-well growth inhibition assays for six patient-derived melanoma cell lines (PDMCLs), three wild type (WT) for BRAF and three with V600E-BRAF mutations. We conducted a pilot drug combination (DC) high-throughput […]
