Next-generation cell therapies: the emerging role of CAR-NK cells
Next-generation cell therapies: the emerging role of CAR-NK cells Receptors in Detail Summary T cells with chimeric antigen receptors (CARs) have transformed cell therapy and shifted the treatment paradigm for many patients with recurrent or refractory B-cell malignancies. Despite this advancement, CAR-T cell treatment has limits in both autologous and allogeneic contexts, including practical, logistical, […]
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy Summary Natural killer (NK) cells are specialized immune cells that can be genetically manipulated to produce capable effector cells for adoptive cellular therapy of cancer patients due to their rapid detection and lysis of malignant cells. However, biological and technical barriers to […]
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany Chimeric Antigen Receptors Summary Chimeric antigen receptor-T cell therapies are poised to become powerful immunotherapeutic tools for combating hematological diseases, which have a pressing need for treatment. Patients characteristics Recently, CAR-NK cell therapy has also come be the focus of new treatment options […]
